NIPER Ahmedabad

Research Activity

• Generation of induced Pluripotent Stem Cells (iPSCs) using nonviral methods and its re-differentiation
• Pharmacogenetics studies and population based genome analyses like genomic alteration in cancer and diabetes
• Cancer research to overcome chemoresistance and prevention of relapse by Cancer Stem Cells (CSCs) re-differentiation and co-lethality approach
• Proteomic and genomic Biomarkers for Diabetes and its microvascular complications
• Role of miRNA in epigenetics and pathogenesis of diabetic nephropathy
• Transcriptome analysis of Oral Squamous Cell Carcinomas patients from Gujarat , India
• Developing bionegineered three-dimensional disease model.
• Separation and purification of therapeutic cell-types e.g. stem cells from intervertebral disc
• Repair and regeneration of musculoskeletal and nerve tissues
• Comparative simulation study of human and rat Aβ aggregation for the development of the potential therapeutic application for the Alzheimer.
• Structure-function relationship of the boronic acid-based ligand with tumor M2PK (M2 pyruvate kinase) protein using structural bioinformatics and molecular dynamics approaches.
• In-silico drug design: Hit to lead optimization.

Research Activity

• Bio-prospecting of endolichenic fungi to discover novel bioactive scaffolds
• LC-MS based dereplication strategy for isolation of natural products from microbial and plant sources
• Fingerprinting herbal extracts by LC-UV-MS for chemical marker identification
• Bioassay-guided isolation, structure elucidation and synthetic modification of bioactive compounds from medicinal plants
• Development of analytical methods for standardization of polyherbal formulations using hyphenated techniques
• To establish Q-markers for the quality standards of traditional Ayurvedic /herbal medicines
• Blending the strategies of synthetic organic chemistry along with the medicinal aspects of natural products for the development of New Chemical Entities (NCEs) against Cancer and Neurodegenerative disorders
• Total Synthesis and semi synthesis of bioactive Natural products and its structural modification via C-H functionalization and C-C coupling reactions
• Design and construction of fluorine containing scaffolds of pharmaceutical importance via C-H Bond activation. Incorporation of Fluorine into the bioactive natural product scaffolds and its biological evaluation

Research Activity

• RNA Interreference (RNAi) therapy: Development of Polymeric Gene Transfecting Reagent for Cancer Therapy. Synthesis of polymeric nanoparticle for effective cytosolic delivery of siRNA, miRNA, plasmids and Oligonucleotides for the treatment of Cancer and Diabetes.
• Nanotechnology-driven Targeted Nanomedicine: Development of Site-specific delivery of therapeutic drugs particularly in areas of our strengths including cancer, diabetes, arthritis, Alzheimer’s, Cerebral stroke, Parkinson’s disease etc.
• Photo-chemo-thermal therapy: Development of NIR-Laser activatable Nanoseeds for the treatment of cancer as well as for the prevention of post-surgical relapse of the resectable tumor.
• Green Synthesis of Nanoparticles: This project aims to develop green and sustainable method for the large-scale production of nanoparticles for imaging and drug delivery applications.
• Microemulsion, Nanoemulsion and Nanocrystals for nose to brain delivery of drug Application of Quality by Design (QbD) in formulation development and optimization of pharmaceutical formulations.
• Physical characterization of pharmaceuticals using Particle size, Surface zeta potential, Rheology, thermal analysis, and imaging techniques.
• Solubility enhancement using nanoparticulate approach, electospraying techniques, nanocrystallization, and co-crystallization and their characterization studiesLipidic nanoformulations and their role in targeting brain, posterior segment of eye, psoriasis etc.

Research Activity

• Design and synthesis of heterocyclic compounds as anticancer and anti-diabetic agents.
• Development of new strategies and concepts in synthetic organic chemistry towards sustainable synthesis of NCEs for anti-cancer drug discovery.
• Computer aided drug designing, docking, simulation studies and study of (quantitative) structure activity relationship.
• Transition metal catalyzed C-H activation reactions of unreactive C-H bond for the synthesis of anticancer and neuroprotective agents.
• Design and construction of fluorine containing scaffolds of pharmaceutical importance via C- H Bond activation.
• Process development of Active Pharmaceutical Ingredients (APIs).
• Re purposing of existing drug molecules for improved PK/PD profiling by modification of non pharmacophoric parts.
• Design and synthesis of peptide-nucleic acids (PNA) targeting m RNA and DNA related to oncology and neurological disorders.
• Synthesis of peptides and peptido-mimetics for targeted delivery and organocatalysis.

Research Activity

• Cellular & molecular mechanisms involved in diabetes and its complications (neuropathy, nephropathy & encephalopathy)
• Development of novel therapeutics for the treatment of spontaneous ongoing pain devoid of drug addiction
• Cellular & molecular mechanisms involved in chronic neuropathic pain and associated CNS co-morbidities
• Role of reward circuitry in peripheral opioid induced neuropathic pain relief
• To develop the animal model of stroke induced chronic pain and develop new therapies against it
• The translational aspect of safety and efficacy of intra-arterial delivery of mesenchymal stem cells in small and large animal model of ischemic stroke and related mechanisms of neuroprotection.
• The regulatory RNA mediated mesenchymal stem cell engineering and nanoparticle based targeted drug delivery to the brain.
• To elucidate mechanisms for the deleterious effect of hyperglycemia in ischemic stroke.
• To explore the endocrine regulation towards neuroprotection in ischemic stroke.

Research Activity

• QbD based analytical and bioanalytical method development
• PK studies and metabolite profiling
• Reverse engineering of complex products and sameness strategy development for regulatory submission
• LC-MS and NMR based impurity profiling of NCEs and approved drugs
• Degradation profiling of drug substances and drug products
• Pre-formulation assessment of drugs including polymorph characterization and drug- excipient compatibility studies
• Stability analysis of drug substance, intermediates and products
• Characterization of complex generics and biosimilars

Research Activity

• Tissue engineering (Intervertebral disc, spinal cord and ocular diseases).
• Biomaterial design and development.
• Polymer modification for biomedical applications
• Cell and exosomes separation
• Smart biomaterials for articular surfaces and musculoskeletal tissue regeneration and care.
• Alternative strategies for cancer theranostics like magnetic hyperthermia and photodynamictherapy.
• Engineered approaches such as electrical and mechanical stimulations for regenerative medicine.
• Synthesis of versatile nanostructured materials (quantum dots, layered nanoparticles andgraphene etc.) for various medical applications.
• Lab-on-chip devices
• Biomimetic designs of microfluidic devices
• Blood microsampling devices for diagnostics
• Passive micropumps for paper microfluidics
• Micro/nanodevices for life-sciences and biomedical applications
• Microdevices for gas/solute exchange applications
• Devices for passive cooling of biomolecules (Proteins/cells)
• Microdevices for drug delivery applications
• Microdevices for cell and tissue culture applications

Objectives of Pharmaceutical Management

NIPER-Ahmedabad offers a two-year full-time M.B.A (Pharm.) Management program in Pharmaceutical Management. This course was started in the year 2020. It is a pioneer informational program focusing on making arranged managers with basic aptitudes in masterminding and working organization systems; diagnosing and dealing with the Management problems.

To Build Skilled & effective professionals for pharma sector, by improving the quality and standards of pharmaceutical education and Management skills.

The Pharmaceutical Management course, evolve and expands the students, over a period of two years by rigorous field work and academics helps them to clinch leading managerial positions in pharmaceutical industry.

To meet and contribute to the rapid growth and diversification of pharmaceutical industries, we at NIPER Ahmedabad are inculcating the knowledge of some advance management programme like:

• Managerial Communication Development.
• Market Research.
• OB & HR Management.
• Pharmaceutical advertising.
• Pharmaceutical Marketing.
• Research and Development management.
• Sales Management.
• Financial Management.
• Intellectual Property Rights.

To make the students well acquainted with the industrial environment and their working behavior, we provide our students 8 weeks of Internship and also field study to expose them in the areas of sales and marketing.

To keep our students engaged and updated about the current pharma affairs and their activities, we are arranging weekly Guest Lectures of eminent personalities from different Pharma spectrum, also we are arranging visiting Lectures of professors from renowned universities.